






KEY BENEFITS
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Preserves Collagen & Firmness
Clinically proven to defend against UV-induced collagen degradation, maintaining your skin's natural bounce and preventing future loss of elasticity.[1]
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Supports Cellular Recovery
The unique combination of two DNA repair enzymes support the skin’s natural repair mechanisms, to prevent visible damage and ageing.[2]
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Non-Absorbing UV-Protection
Powerful SPF 50 PA++++ protection against the damaging effects of UVA (ageing) & UVB (burning). Encapsulation technology ensures the filters don't pass the skin barrier.[3]
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Shields Against Pollution
Protects the skin from the ageing effects of daily environmental damage, and pollution.[4]
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Invisible, All Day Hydration
Deeply nourishing, all day hydration that absorbs instantly with a velvet-matte feel. A completely weightless formula that layers perfectly under makeup without pilling.[5]
View Citations
[1] In skin exposed to solar-simulated UV radiation, Age Defence significantly reduced MMP1 expression, a key enzyme involved in collagen breakdown, compared to untreated UV-exposed controls.
[2] Emanuele, E., Spencer, J. M., & Braun, M. (2014). Topical Application of Preparations Containing DNA Repair Enzymes Prevents Ultraviolet-Induced Telomere Shortening and c-FOS Proto-Oncogene Hyperexpression in Human Skin: An Experimental Pilot Study. Journal of Drugs in Dermatology (JDD), 13(3), 304-309.
[3] Proven in independent clinical and laboratory testing, including in-vivo SPF 50 and PA++++ validation, structural analysis confirming a 1-micron capsule size that prevents skin absorption, and a 52-subject dermatological patch test demonstrating no adverse reactions.
[4] Supported by peer-reviewed clinical research demonstrating that topical application of Vaccinium myrtillus (Bilberry) provides significant antioxidant defence against oxidative stress and environmental skin ageing.
[5] Proven in an independent clinical study to provide 24 hour hydration.
As Featured In
Pure Science. Proven Results
Proven Results
Rigorously tested across all three dimensions of our Cell-to-Surface™ standard
Biological Efficacy
In skin exposed to solar-simulated UV radiation, Age Defence reduced the expression of key biomarkers associated with collagen degradation (MMP1), inflammation (PTGES), and cellular senescence (P21), compared to untreated UV-exposed controls.
Clinical Study
Consumer Validated
Formulation Science
A Note from Dr. Clare Kiely
“As a dermatologist specialising in skin cancer, I see the cumulative effects of UV exposure and environmental damage every day in my clinic. I always tell my patients that the single most powerful tool for maintaining skin health is consistent daily protection, starting with sunscreen. However, I also understand the reality: many people dislike wearing traditional high-SPF products — they can feel heavy, congesting, and disrupt makeup. If a product isn’t a pleasure to use, it won’t be used consistently, and inconsistent protection leaves the skin vulnerable.
Age Defence was created to bridge the gap between rigorous dermatological science and elegant skincare. My goal was to develop a formula that delivers high-level, broad-spectrum UV protection while feeling like a lightweight, luxurious day cream. By combining advanced encapsulated filters with ingredients inspired by DNA repair mechanisms, this formula helps defend against daily environmental damage while supporting the skin’s natural recovery processes.”
Ingredients
By precisely pairing encapsulated, non-absorbing UV filters with targeted DNA repair enzymes and pollution-neutralising antioxidants, we have created a daily formula where surface protection and deep environmental defence actively work in tandem.
Protect — Ethylhexyl Methoxycinnamate, Butyl Methoxydibenzoylmethane, Octocrylene (encapsulated in oil-water-oil lipids). Advanced encapsulated UV filters provide all the benefits of chemical sunscreen filters without absorption, making them sensitive-skin friendly and non-greasy. An antioxidant complex of bilberry extract and raspberry seed oil shields against pollution and environmental stressors that lead to dullness.
Renew — Micrococcus Lysate, Plankton Extract. Phytoshield DNA repair: photolyase and endonuclease act as a biological ‘search and support’ team that aids the skin's natural recovery from UV exposure.
Restore — Squalane, Lecithin, Maleated Soybean Oil Glyceryl/Octyldodecanol Esters, Glycerin, Butylene Glycol, Raspberry Seed Oil, Sunflower Seed Oil, Vitamin E. Barrier-identical lipids and humectants mimic the skin's natural composition to deeply hydrate, restore suppleness, and lock in moisture all day.
Full INCI: Aqua, Ethylhexyl Methoxycinnamate, Butyl Methoxydibenzoylmethane, Squalane, Glyceryl Citrate/Lactate/Linoleate/Oleate, Octocrylene, Butylene Glycol, Rubus Idaeus Seed Oil, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Glycerin, Maleated Soybean Oil Glyceryl/Octyldodecanol Esters, Plankton Extract, Micrococcus Lysate, Vaccinium Myrtillus Fruit Extract, Helianthus Annuus Seed Oil, Lecithin, Tocopherol, Polysorbate 60, Sodium Acrylates Copolymer, Ethylhexylglycerin, Sorbitan Isostearate, Citric Acid, Sodium Benzoate, Phenethyl Alcohol, Hydroxyacetophenone, Potassium Sorbate, Parfum, Geraniol, Limonene, Linalool, Sodium Hydroxide, Phenoxyethanol.
How to Use
For best results, we recommend the multi-dot technique to ensure even, full coverage across the face and neck.
How to apply: Dispense 3–4 pumps of Age Defence. Dot the product evenly across your face and neck (forehead, cheeks, chin, nose, and neck). Gently smooth into the skin until fully absorbed.
When to use: Apply every morning as the final step in your skincare routine, always to clean skin. Designed to protect and hydrate throughout the day with SPF 50.

DNA repair enzymes
Nobel Prize Inspired Science
Our skin is constantly exposed to environmental stressors such as UV radiation, which can damage cellular DNA.
In 2015, the Nobel Prize in Chemistry was awarded for discoveries explaining how cells repair this damage. This research included repair mechanisms, including photoreactivation (a light-driven process involving the enzyme photolyase) and nucleotide excision repair.
In human skin, DNA damage is primarily repaired through nucleotide excision repair, as photolyase is not naturally present.
Modern skincare technologies are inspired by these biological systems, aiming to support the skin’s natural recovery processes. Research continues to evolve and these innovations remain an exciting area of skin science.
HOW THE ENZYMES WORK
Photolyase (The Daylight Defender):A brilliant light-activated enzyme. It actually uses the energy from daylight to help support the skin's natural biological mechanisms against UV-induced stress.
Endonuclease (The Deep Support): Works in tandem to help the skin's ecosystem identify and recover from the invisible, microscopic environmental damage that standard SPFs leave behind.

A Global Authority in Skin Ageing
Formulated by Dr. Clare Kiely
Dr. Clare Kiely is Chief Medical Officer and a founding dermatologist at The Skin Diary, specialising in skin cancer and the clinical effects of daily UV exposure.
“I always tell my patients that the single most powerful tool for maintaining skin health is consistent daily protection, starting with sunscreen,” says Dr. Kiely. “Age Defence was created to bridge the gap between rigorous dermatological science and elegant skincare — a formula that delivers high-level, broad-spectrum UV protection while feeling like a lightweight, luxurious day cream.”
By combining advanced encapsulated filters with ingredients inspired by DNA repair mechanisms, Age Defence helps defend against daily environmental damage while supporting the skin's natural recovery processes.